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Which type of oil should you be injecting testosterone therapy with?


We are writing to inform you of the latest development in testosterone administration. For those of you that don’t know, there are three oil bases used in testosterone compounding: sesame seed oil, cottonseed oil, and grapeseed oil. All three of these are different when it comes to the inflammatory response they can cause in our bodies. We at MHI have been typically prescribing testosterone in grapeseed oil due to its low viscosity and inflammatory response. Please note, the more inflammation, the more water retention you will experience. So let’s discuss the three base types of oils used in testosterone and the newest one on the block: “MCT” oil base.



Cottonseed oil


This oil base is used in 99% of all testosterone brand names. It is the most inflammatory of all the oils. Cottonseed is not food nor a substance that is truly recognized by our bodies, hence our body’s negative response. It is well known that cottonseed oil can cause health problems like infertility, liver damage, pregnancy problems, respiratory distress, and anorexia to name a few, all while being far more expensive than the compounded versions. For these reasons we certainly find this oil base to be the least desirable option.


cottonseed oil injecting testosterone therapy


Sesame seed oil


This oil is the most commonly used by compounding pharmacies. With the years we’ve seen that, by default, compounding pharmacies use this base unless requested otherwise. We reckon this has to do with production and cost. In terms of its inflammatory response we find this oil base to be in 2nd place.


sesame seed oil testosterone therapy injections


Grapeseed oil


In regards to overall health, this seed extract provides the body with many health benefits like improved blood flow, can reduce oxidative damage, and reduction of blood pressure. Mainly though, we know this oil-base is the least inflammatory injectable oil in the industry which is why we make it our default choice on all our testosterone prescriptions. Though now, a new oil has found the spotlight – Medium Chain Triglycerides oil or “MCT oil”.




MCT oil not only has potent anti-inflammatory properties but also has antimicrobial and antifungal effects. In food, MCT oil has been shown to support weight and fat loss. Moreover, MCT oil can also increase the production of heart-protective HDL or “good” cholesterol. It can even significantly reduce C-reactive protein (CRP), which is an inflammatory marker that increases the risk of heart disease. MCT oil is easy to absorb and use, it offers the digestive system a break and is often a fantastic choice for those who struggle with digestive problems, fat absorption, or lack a gallbladder. Judging from the results we’ve seen with our patients this is our preferred oil base for injectable testosterone administration.


injecting testosterone therapy with mct oil


We hope this blog has been useful. If you have any questions about this subject please make sure to get with your assigned care coordinator and ask him any additional questions you may have. Also, be sure to ask about our new tri-blend (Cypionate/Enanthate/Propionate) injectable testosterone in MCT oil.  This will be the subject of next week’s newsletter: the pharmacodynamics of these medications.

To learn more about TRT go to our Testosterone Replacement Therapy page. To Schedule your free consultation contact us now.


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