While each of these growth hormone secretagogues operate through unique mechanisms and serve distinct functions, their collective aim is to optimize the body’s efficiency in the areas of: Energy, Stamina, Strength, Muscle Growth, Fat Burning, Exercise Recovery, Improved Sleep Quality, Joint & Tissue Health, Skin Elasticity, Immune function, Wound Healing, Lipid Stabilization, Anti-Aging Effects
Before you proceed, let us clarify a few key terms related to these specific types of peptides. Put simply, the primary role of these peptides is to stimulate the secretion of growth hormone.These growth hormone secretagogues fall into two categories.
What is a GHRH (Growth Hormone-Releasing Hormone)
​A GHRH triggers the hypothalamus and pituitary gland to release more growth hormone from the brain to the liver.
What is a GHRP (Growth Hormone-Releasing Peptide)
A GHRP triggers the liver to release growth hormone into the bloodstream.
To help illustrate the distinction, think of growth hormone as the fuel powering a race car. A GHRH acts like a pit crew member refilling the car with more fuel while a GHRP acts as a skilled pilot engaging a turbocharger to boost the car’s performance as needed.
NOTE: Because GHRHs “fill the tank” and GHRPs “empty the tank” they are exceptionally complimentary, and can be used in combination for greater results.
While each of these growth hormone secretagogues operate through unique mechanisms and serve distinct functions, their collective aim is to optimize the body's efficiency in the areas of:
- Energy/Stamina/Strength
- Muscle Growth
- Fat Burning
- Exercise Recovery
- Improved Sleep Quality
- Joint & Tissue Health
- Skin Elasticity
- Immune function
- Wound Healing
- Lipid Stabilization
- "Anti-Aging" Effects
Tesamorelin (GHRH)
44 amino acids
5-6 hour half-life
This GHRH has shown to increase IGF-1 levels in men and women by an average of 181 micrograms/liter. This is by far the strongest & most effective peptide at increasing IGF-1 levels.
Here is a study on the benefits of Tesamorelin by the National Center for Biotechnology Information (NCBI)
5-6 hour half-life
This GHRH has shown to increase IGF-1 levels in men and women by an average of 181 micrograms/liter. This is by far the strongest & most effective peptide at increasing IGF-1 levels.
Here is a study on the benefits of Tesamorelin by the National Center for Biotechnology Information (NCBI)
Ipamorelin (GHRP)
5 Amino Acids
2 hour half-life
Unlike other growth hormone-secretagogues, this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin, and aldosterone as other peptides can. For this reason it has been considered the first & best selective growth hormone-secretagogue.
Here is a study about the benefits of Ipamorelin by PubMed Central (PMC)
2 hour half-life
Unlike other growth hormone-secretagogues, this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin, and aldosterone as other peptides can. For this reason it has been considered the first & best selective growth hormone-secretagogue.
Here is a study about the benefits of Ipamorelin by PubMed Central (PMC)
MK-677 (GHRP)
24 hour half-life
Is neither a peptide nor a SARM (selective androgen receptor modulator). It is actually classified as a growth hormone secretagogue. It works by stimulating the release of growth hormone and increasing levels of insulin-like growth factor 1 (IGF-1) in the body. It’s an oral compoundI that stimulates the release of growth hormone by binding to the ghrelin (28 amino acids) receptors. It’s main target in our biochemistry is to increase muscle growth.
Here is a study about the benefits of MK-677 by PubMed Central (PMC)
Is neither a peptide nor a SARM (selective androgen receptor modulator). It is actually classified as a growth hormone secretagogue. It works by stimulating the release of growth hormone and increasing levels of insulin-like growth factor 1 (IGF-1) in the body. It’s an oral compoundI that stimulates the release of growth hormone by binding to the ghrelin (28 amino acids) receptors. It’s main target in our biochemistry is to increase muscle growth.
Here is a study about the benefits of MK-677 by PubMed Central (PMC)
CJC-1295 (GHRH)
29-amino acids
30 minute half-life
This is a tetrasubstituted peptide shown to increase growth hormone in enormous amounts. CJC 1295 will keep a steady increase of HGH and IGF-1 with no increase in prolactin.
Here is a study about the benefits of CJC 1295 by the National Institutes of Health (NIH)
30 minute half-life
This is a tetrasubstituted peptide shown to increase growth hormone in enormous amounts. CJC 1295 will keep a steady increase of HGH and IGF-1 with no increase in prolactin.
Here is a study about the benefits of CJC 1295 by the National Institutes of Health (NIH)
Sermorelin (GHRH)
29 amino acids
10-20 minute half-life
This ia “first generation” growth hormone secretagogue peptide. Although effective, it has shown to increase more prolactin and cortisol than other GHRH/GHRP peptides.
Here is a study about the benefits of Sermorelin by PubMed Central (PMC)
10-20 minute half-life
This ia “first generation” growth hormone secretagogue peptide. Although effective, it has shown to increase more prolactin and cortisol than other GHRH/GHRP peptides.
Here is a study about the benefits of Sermorelin by PubMed Central (PMC)
IGF-1 LR3 (Polypeptide)
83 Amino Acids
20-30 hour half-life
A polypeptide is a longer chain of amino acids, typically containing more than 50 amino acids. IGF-1 LR3 is a modified version of insulin-like growth factor 1 (IGF-1) that has an extended half-life compared to natural IGF-1. LR3 activates both the mitogen-activated protein (MAP) kinase and PI3K signaling pathways, acting in almost every tissue of the body. It is most often used to stimulate muscle growth, and significantly increases the body’s sensitivity to insulin, which in turn mobilizes fat for use as energy. In lean tissue mass, IGF-1 LR3 prevents insulin from transporting glucose across cell membranes. As a result, the cells have to switch to burning off fat as a source of energy.
Here is a study about the benefits of IGF-1 LR3 by PubMed Central (PMC)
20-30 hour half-life
A polypeptide is a longer chain of amino acids, typically containing more than 50 amino acids. IGF-1 LR3 is a modified version of insulin-like growth factor 1 (IGF-1) that has an extended half-life compared to natural IGF-1. LR3 activates both the mitogen-activated protein (MAP) kinase and PI3K signaling pathways, acting in almost every tissue of the body. It is most often used to stimulate muscle growth, and significantly increases the body’s sensitivity to insulin, which in turn mobilizes fat for use as energy. In lean tissue mass, IGF-1 LR3 prevents insulin from transporting glucose across cell membranes. As a result, the cells have to switch to burning off fat as a source of energy.
Here is a study about the benefits of IGF-1 LR3 by PubMed Central (PMC)
